Given this heterogeneity, we next tested whether these lesion locations shared a specific pattern of brain connectivity ( Figure 3). Six representative lesions (green) selected from 41 literature cases demonstrate heterogeneity in lesion location. Lesions associated with mania occur in multiple different brain locations. Here, it was applied to 2 independent cohorts of lesions associated with mania. By mapping symptoms to brain networks, rather than single brain regions, this technique has lent insight into mechanisms underlying a variety of neuropsychiatric symptoms ( 4, 20, 25, 26). Rather than focus on lesion locations alone, this approach examines the network of regions functionally connected to each lesion, using resting-state functional connectivity ( 21, 22) from a large database of healthy volunteers ( n = 1000) ( 23, 24). A recently developed technique, termed lesion network mapping, is well suited to test this hypothesis ( 3, 20). These authors hypothesized that lesions causing mania may map to a limbic circuit involving the orbitofrontal cortex, basotemporal cortex, and basal ganglia ( 9– 19). In seminal work by Starkstein and Robinson, lesions associated with mania were found to be more common in the right hemisphere, but occurred in numerous different brain regions ( 9– 19). It is characteristic of bipolar I disorder, but has been reported following focal brain lesions for nearly a century ( 8). However, judging whether new-onset psychiatric symptoms are attributable to a structural brain lesion can be complicated by incidental findings on neuroimaging ( 5), potential delays between the lesion and the resulting symptoms ( 6), and because the same symptoms can be caused by damage to multiple different brain regions ( 7). Such cases are of interest as they can provide causal links between brain regions or circuits and specific psychiatric symptoms, and lead to identification of therapeutic targets ( 3, 4). (12.00H New York / 18.00H Paris / 24.Patients presenting with psychiatric symptoms after focal brain damage challenge the boundaries between neurology and psychiatry ( 1, 2). Half Day Educational Course: Bridging Electrophysiology and Neuroimaging to Understand Brain Dynamics Half Day Educational Course: Time-varying Connectivity in Resting-state fMRI: Methods, interpretations, and clinical useįull Educational Course: Deep Learning for Human Brain Mapping (4.00H New York / 10.00H Paris / 16.00H Beijing)įull Educational Course: Fundamental Concepts and Methods in Network Neuroscience (20.00H New York / 2.00H Paris / 8.00H Beijing)įull Educational Course: Machine Learning for Neuroimaging, Learn the Basics before Going Deeper Half Day Educational Course: Advanced Techniques for Functional and Structural Neuroimaging of the Cerebellumįull Educational Course (Part II): Analysis Methods for Naturalistic Data Half Day Educational Course: EEG Data Acquisition and Appropriate Data Pre-processing: Not so basic after all Half Day Educational Course: Researcher's Guide to the Adolescent Brain Cognitive Development (ABCD) Study: Release 3.0 (10.00H New York / 16.00H Paris / 22.00H Beijing)įull Educational Course(Part I): Analysis Methods for Naturalistic Data Half Day Educational Course: Brain Parcellations and Functional Territories
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Half Day Educational Course: Population Neuroimaging: How to responsibly handle big data in the age of biobanks To register for the Education Course component, please click here:ĮDUCATION COURSES - ENGAGEMENT LOUNGE SCHEDULE Through interactive Q&A, attendees will also have the chance to network with course organizers and presenters by participating in an Engagement Lounge that has been scheduled for each Education Course starting Wednesday, July 15th through Friday, July 17th. Attendees will have the opportunity to watch the pre-recorded content at their leisure. Education Courses will be launched on Monday, July 13 that midnight EDT.
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